The Views Of Physician-Scientist, Dr. Mikhail Blagosklonny On Proximal Causes Of Ageing

Recent studies have suggested that aging does not occur due to any kind of molecular damage. It is not due to any random damage either. The relationship exists between disease and aging. This is quite apparent to all, but Dr. Mikhail Blagosklonny likes to talk about all this in more detail.


When the actual proliferation tends to get blocked in cell culture, it will still have active pathways. These would signal growth and be able to sense the nutrients too. This would also include Target of Rapamycin pathway. This way the quiescent cells are converted to senescent cells. No molecular damage will be happening here. Such a pathway is present in all kinds of organisms ranging from yeast to worms to mammals. Such kind of a pathway that drives developmental growth can later drive aging too along with its associated diseases. According to Dr. Mikhail Blagosklonny, aging is a useless run of these developmental programs. The cellular senescence here will refer to continued cell growth. Hence any type of over-stimulation here will lead to an increase in these functions that include secretion by fibroblasts, and any kind of contraction by the arterial smooth muscle cells, besides the aggregation by platelets. View his LinkedIn profile

Also, there can be bone resorption which will be by the osteoclasts, and the lipogenesis by fat cells. Other functions included the glycogenesis by liver cells besides the inflammation by neutrophils, the phagocytosis by macrophages and so on. In the case of overstimulation, there can be cell signal resistance. It can be because the signaling pathways are blocked. In case of hyper-function along with signal-resistance, there can be a loss of homeostasis besides several diseases, organ damage that can lead to the eventual death of the organism. This would mean that any kind of hyper-functions of the arterial smooth muscle cells, macrophages, hepatocytes and the fat cells, blood platelets, neurons as well as fibroblasts may result in age-related blindness, and gangrenes, renal, heart failure, and even cancer.

  1. Mikhail Blagosklonny finds chronic inflammation as another example of hyper-function. It is associated with aging and other diseases that are age-related.

Visit to read more about Mikhail.

Comments are disabled